Blar i forfatter "Matullo, Giuseppe"

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    • Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study 

      Ricci, Cristian; Wood, Angela; Muller, David; Gunter, Marc J.; Agudo, Antonio; Boeing, Heiner; van der Schouw, Yvonne T.; Warnakula, Samantha; Saieva, Calogero; Spijkerman, Annemieke M.W.; Sluijs, Ivonne; Tjønneland, Anne; Kyrø, Cecilie; Weiderpass, Elisabete; Kühn, Tilman; Kaaks, Rudolf; Sánchez, Maria-Jose; Panico, Salavatore; Agnoli, Claudia; Palli, Domenico; Tumino, Rosario; Engström, Gunnar; Melander, Olle; Bonnet, Fabrice; Boer, Jolanda M.A.; Key, Timothy J.; Travis, Ruth C.; Overvad, Kim; Verschuren, W.M. Monique; Quirós, José Ramón; Trichopoulou, Antonia; Papatesta, Eleni-Maria; Peppa, Eleni; Iribas, Conchi Moreno; Gavrila, Diana; Forslund, Ann-Sofie; Jansson, Jan-Håkan; Matullo, Giuseppe; Arriola, Larraitz; Freisling, Heinz; Lassale, Camille; Tzoulaki, Ioanna; Sharp, Stephen J.; Forouhi, Nita G.; Langenberg, Claudia; Saracci, Rodolfo; Sweeting, Michael; Brennan, Paul; Butterworth, Adam S.; Riboli, Elio; Wareham, Nicholas J.; Danesh, John; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-29)
      Objective To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke.<p> <p>Design Multicentre case-cohort study.<p> <p>Setting A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European ...

    • Association of menopausal characteristics and risk of coronary heart disease: A pan-European case-cohort analysis 

      Dam, Veerle; van der Schouw, Yvonne T.; Onland-Moret, N. Charlotte; Groenwold, Rolf H.H.; Peters, Sanne A.E.; Burgess, Stephen; Wood, Angela M.; Chirlaque, Maria-Dolores; Moons, Karel G.M.; Oliver-Williams, Clare; Schuit, Ewoud; Tikk, Kaja; Weiderpass, Elisabete; Holm, Marianne; Tjønneland, Anne; Kühn, Tilman; Fortner, Renée T.; Trichopoulou, Antonia; Karakatsani, Anna; La Vecchia, Carlo; Ferrari, Pietro; Gunter, Marc; Masala, Giovanna; Sieri, Sabina; Tumino, Rosario; Panico, Salvatore; Boer, Jolanda M.A.; Verschuren, W.M. Monique; Salamanca-Fernández, Elena; Arriola, Larraitz; Moreno-Iribas, Conchi; Engström, Gunnar; Melander, Olle; Nordendahl, Maria; Wennberg, Patrik; Key, Timothy J.; Colorado-Yohar, Sandra; Matullo, Giuseppe; Overvad, Kim; Clavel-Chapelon, Francoise; Boeing, Heiner; Ramõn Quirõs, Jose; di Angelantonio, Emanuele; Langenberg, Claudia; Sweeting, Michael J.; Riboli, Elio; Wareham, Nicholas J.; Danesh, John; Butterworth, Adam (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-22)
      <i>Background</i> - Earlier age at menopause has been associated with increased risk of coronary heart disease (CHD), but the shape of association and role of established cardiovascular risk factors remain unclear. Therefore, we examined the associations between menopausal characteristics and CHD risk; the shape of the association between age at menopause and CHD risk; and the extent to which these ...

    • Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort 

      Allione, Alessandra; Viberti, Clara; Cotellessa, Ilaria; Catalano, Chiara; Casalone, Elisabetta; Cugliari, Giovanni; Russo, Alessia; Guarrera, Simonetta; Mirabelli, Dario; Sacerdote, Carlotta; Gentile, Marco; Eichelmann, Fabian; Schulze, Matthias B.; Harlid, Sophia; Eriksen, Anne Kirstine; Tjønneland, Anne; Andersson, Martin; Dollé, Martijn E.T.; Van Puyvelde, Heleen; Weiderpass, Elisabete; Rodriguez-Barranco, Miguel; Agudo, Antonio; Heath, Alicia K.; Chirlaque, María-Dolores; Truong, Thérèse; Dragic, Dzevka; Severi, Gianluca; Sieri, Sabina; Sandanger, Torkjel M; Ardanaz, Eva; Vineis, Paolo; Matullo, Giuseppe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-28)
      Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mainly caused by asbestos exposure. Specific and sensitive noninvasive biomarkers may facilitate and enhance screening programs for the early detection of cancer. We investigated DNA methylation (DNAm) profiles in MPM prediagnostic blood samples in a case-control study nested in the European Prospective Investigation into Cancer ...

    • Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition 

      Bradbury, Kathryn E.; Appleby, Paul N.; Tipper, Sarah J.; Travis, Ruth C.; Allen, Naomi E.; Kvaskoff, Marina; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Cervenka, Iris; Mahamat-Saleh, Yahya; Bonnet, Fabrice; Kaaks, Rudolf; Fortner, Renée T.; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Stratigos, Alexander J.; Palli, Domenico; Grioni, Sara; Matullo, Giuseppe; Panico, Salvatore; Tumino, Rosario; Peeters, Petra H.; Bueno-de-Mesquita, H. Bas; Ghiasvand, Reza; Veierød, Marit B.; Weiderpass, Elisabete; Bonet, Catalina; Molina, Elena; Huerta, José M.; Larrañaga, Nerea; Barricarte, Aurelio; Merino, Susana; Isaksson, Karolin; Stocks, Tanja; Ljuslinder, Ingrid; Hemmingsson, Oskar; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc J.; Rinaldi, Sabina; Tsilidis, Konstantinos K.; Aune, Dagfinn; Riboli, Elio; Key, Timothy J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-07)
      Insulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations ...

    • Consumption of meat, fish, dairy products, and eggs and risk of ischemic heart disease: A prospective study of 7198 incident cases among 409 885 participants in the Pan-European EPIC Cohort 

      Key, Timothy J.; Appleby, Paul N.; Bradbury, Kathryn E.; Sweeting, Michael; Wood, Angela; Johansson, Ingegerd; Kühn, Tilman; Steur, Marinka; Weiderpass, Elisabete; Wennberg, Maria; Würtz, Anne Mette Lund; Agudo, Antonio; Andersson, Jonas; Arriola, Larraitz; Boeing, Heiner; Boer, Jolanda M.A.; Bonnet, Fabrice; Boutron-Ruault, Marie-Christine; Cross, Amanda J.; Ericson, Ulrika; Fagherazzi, Guy; Ferrari, Pietro; Gunter, Marc; Huerta, José María; Katzke, Verena; Khaw, Kay-Tee; Krogh, Vittorio; La Vecchia, Carlo; Matullo, Giuseppe; Moreno-Iribas, Conchi; Naska, Androniki; Nilsson, Lena Maria; Olsen, Anja; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Molina-Portillo, Elena; Quirós, J. Ramón; Skeie, Guri; Sluijs, Ivonne; Sonestedt, Emily; Stepien, Magdalena; Tjønneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; Tzoulaki, Ioanna; van der Schouw, Yvonne T.; Verschuren, W.M. Monique; di Angelantonio, Emanuele; Langenberg, Claudia; Forouhi, Nita; Wareham, Nick; Butterworth, Adam; Riboli, Elio; Danesh, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)
      <i>Background</i> - There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition).<P><P> <i>Methods</i> - In this prospective study of 409 885 men and women in 9 European countries, diet ...

    • Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort 

      Fortner, Renée T.; Vitonis, Allison F.; Schock, Helena; Hüsing, Anika; Johnson, Theron; Fichorova, Raina Nakove; Fashemi, Titilayo; Yamamoto, Hidemi S.; Tjønneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, Marie-Christine; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; La Vecchia, Carlo; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giuseppe; Mattiello, Amalia; Onland-Moret, N. Charlotte; Peeters, Petra H.; Weiderpass, Elisabete; Gram, Inger Torhild; Jareid, Mie; Quirós, José Ramón; Duell, Eric J.; Sánchez, Mariá-José; Chirlaque, María-Dolores; Ardanaz, Eva; Larrañaga, Nerea; Nodin, Björn; Brändstedt, Jenny; Idahl, Annika; Khaw, Kay-Tee; Allen, Naomi; Gunter, Marc; Johansson, Mattias; Dossus, Laure; Merritt, Melissa A.; Riboli, Elio; Cramer, Daniel W.; Kaaks, Rudolf; Terry, Kathryn L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-20)
      Background: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. <br>Methods: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls ( n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition ...

    • Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization 

      Dam, Veerle; Onland-Moret, N. Charlotte; Burgess, Stephen; Chirlaque, Maria Dolores; Peters, Sanne A.E.; Schuit, Ewoud; Tikk, Kaja; Weiderpass, Elisabete; Oliver-Williams, Clare; Wood, Angela M.; Tjønneland, Anne; Dahm, Christina C; Overvad, Kim; Boutron-Rualt, Marie-Christine; Schulze, Matthias B.; Trichopoulou, Antonia; Ferrari, Pietro; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Matullo, Giuseppe; Panico, Salvatore; Boer, Jolanda M. A.; Verschuren, W.M. Monique; Waaseth, Marit; Pérez, María José Sánchez; Amiano, Pilar; Imaz, Liher; Moreno-Iribas, Conchi; Melander, Olle; Harlid, Sophia; Nordendahl, Maria; Wennberg, Patrik; Key, Timothy J.; Riboli, Elio; Santiuste, Carmen; Kaaks, Rudolf; Katzke, Verena; Langenberg, Claudia; Wareham, Nicholas J.; Schunkert, Heribert; Erdmann, Jeanette; Willenborg, Christina; Hengstenberg, Christian; Kleber, Marcus E.; Delgado, Graciela; März, Winfried; Kanoni, Stavroula; Dedoussis, George; Deloukas, Panos; Nikpay, Majid; McPherson, Ruth; Scholz, Markus; Teren, Andrej; Butterworth, Adam S.; van der Schouw, Yvonne T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-20)
      Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.<p> <p>Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD ...

    • Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort 

      Gasull, Magda; Pumarega, José; Kiviranta, Hannu; Rantakokko, Panu; Raaschou-Nielsen, Ole; Bergdahl, Ingvar A.; Sandanger, Torkjel M; Goñi, Fernando; Cirera, Lluís; Donat-Vargas, Carolina; Alguacil, Juan; Iglesias, Mar; Tjønneland, Anne; Overvad, Kim; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Johnson, Theron; Kühn, Tilman; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Verschuren, Monique; Vermeulen, Roel; Rylander, Charlotta; Nøst, Therese Haugdahl; Rodriguez-Barranco, Miguel; Molinuevo, Amaia; Chirlaque, Maria-Dolores; Ardanaz, Eva; Sund, Malin; Key, Tim; Ye, Weimin; Jenab, Mazda; Michaud, Dominique; Matullo, Giuseppe; Canzian, Federico; Kaaks, Rudolf; Nieters, Alexandra; Nöthlings, Ute; Jeurnink, Suzanne; Chajes, Veronique; Matejcic, Marco; Gunter, Marc; Aune, Dagfinn; Riboli, Elio; Agudo, Antoni; Gonzalez, Carlos Alberto; Weiderpass, Elisabete; Bueno-de-Mesquita, Hendrik Bastiaan; Duell, Eric J.; Vineis, Paolo; Porta, Miquel (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-23)
      <i>Background</i> - The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.<p> <p><i>Objectives</i> - First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation ...

    • Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study 

      Campa, Daniele; Barrdahl, Myrto; Santoro, Aurelia; Severi, Gianluca; Baglietto, Laura; Omichessan, Hanane; Tumino, Rosario; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Weiderpass, Elisabete; Chirlaque, Maria-Dolores; Rodríguez-Barranco, Miguel; Agudo, Antonio; Gunter, Marc; Dossus, Laure; Krogh, Vittorio; Matullo, Giuseppe; Trichopoulou, Antonia; Travis, Ruth C.; Canzian, Federico; Kaaks, Rudolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-17)
      <p><i>Background</i>: Leukocyte telomere length (LTL) and mitochondrial genome (mtDNA) copy number and deletions have been proposed as risk markers for various cancer types, including breast cancer (BC).</p> <p><i>Methods</i>: To gain a more comprehensive picture on how these markers can modulate BC risk, alone or in conjunction, we performed simultaneous measurements of LTL and mtDNA copy number ...

    • Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis 

      Fiorito, Giovanni; McCrory, Cathal; Robinson, Oliver; Carmeli, Cristian; Rosales, Carolina Ochoa; Zhang, Yan; Colicino, Elena; Dugué, Pierre-Antoine; Artaud, Fanny; McKay, Gareth J.; Jeong, Ayoung; Mishra, Pashupati P.; Nøst, Therese Haugdahl; Krogh, Vittorio; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Palli, Domenico; Matullo, Giuseppe; Guarrera, Simonetta; Gandini, Martina; Bochud, Murielle; Dermitzakis, Emmanouil; Muka, Taulant; Schwartz, Joel; Vokonas, Pantel S.; Just, Allan; Hodge, Allison M.; Giles, Graham G.; Southey, Melissa C.; Hurme, Mikko A.; Young, Ian; McKnight, Amy Jayne; Kunze, Sonja; Waldenberger, Melanie; Peters, Annette; Schwettmann, Lars; Lund, Eiliv; Baccarelli, Andrea; Milne, Roger L.; Kenny, Rose A.; Elbaz, Alexis; Brenner, Hermann; Kee, Frank; Voortman, Trudy; Probst-Hensch, Nicole; Lehtimäki, Terho; Elliot, Paul; Stringhini, Silvia; Vineis, Paolo; Polidoro, Silvia (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-14)
      <p>Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. <p>We examined the ...